Search | Engineering

订阅投稿

首页工程期刊工程焦点工程成就工程前沿关于我们 English

资源类型

期刊论文 7

年份

2024 1

2022 1

2017 1

2015 1

2014 1

2007 2

关键词

microRNA(miRNA) 1

周围神经 1

器官短缺 1

图谱 1

大脑 1

扩大标准供体 1

时空 1

机械灌注+ 1

皮肤 1

神经 1

组织工程 1

肌肉 1

肝移植 1

肝脏 1

血管系统 1

诱发皮层电位 1

非编码RNA(ncRNA) 1

展开︾

检索范围：

排序：展示方式：

Progress and perspectives of neural tissue engineering

null

《医学前沿（英文）》 2015年第9卷第4期页码 401-411 doi: 10.1007/s11684-015-0415-x

摘要：

Traumatic injuries to the nervous system lead to a common clinical problem with a quite high incidence and affect the patient’s quality of life. Based on a major challenge not yet addressed by current therapeutic interventions for these diseases, a novel promising field of neural tissue engineering has emerged, grown, and attracted increasing interest. This review provides a brief summary of the recent progress in the field, especially in combination with the research experience of the author’s group. Several important aspects related to tissue engineered nerves, including the theory on their construction, translation into the clinic, improvements in fabrication technologies, and the formation of a regenerative environment, are delineated and discussed. Furthermore, potential research directions for the future development of neural tissue engineering are suggested.

关键词： nerve injury tissue engineering nerve grafts

HTML PDF 收藏

Partial portacaval shunt with H-grafts to treat portal hypertension

XU Geliang, HU Hejie, LI Jiansheng, YANG Shugao, CHAI Zhongpei, XU Rongnan

《医学前沿（英文）》 2007年第1卷第3期页码 279-281 doi: 10.1007/s11684-007-0053-z

摘要： Partial portosystemic shunts have been popularized because of a reported low rate of mortality and morbidity (especially encephalopathy, liver failure and occlusion). The results of partial portacaval shunts [small-diameter expanded polytetrafluoroethylene (ePTFE) H-graft portacaval shunt] were retrospectively reviewed to evaluate the clinical efficacy in the treatment of portal hypertension. Forty-three patients with portal hypertension were treated by small-diameter H-graft of ePTFE portacaval shunt from May 1995 to April 2006. Thirty-three had externally ringed grafts and ten had non-ringed ones. Ten had grafts of 10 mm in diameter and 33 had grafts of 8 mm. The left gastric artery and coronary vein were ligated in all the cases. Six had pericardial devascularization and splenectomy was performed in 42. An average decrease of free portal pressure (FPP) from (33.24 ± 4.78) cmHO before shunting and (13.65 ± 5.65) cmHO after shunting was observed. The portal blood flow was reduced by one-third of that before shunt. Thirty-eight patients survived and no upper gastro-intestinal rebleeding occurred in the follow-up period (50.5 months in average). Two were out of contact. Color Doppler ultrasonography and/or portography revealed the shunts were patent in 38 cases and were occluded in three cases (3/41, 7.3%). Encephalopathy developed in five cases (5/41, 12.2%). Partial (small-diameter ePTFE H-graft) portacaval shunting can reduce the portal pressure effectively. Majority of the hepatic flow from the portal vein can be maintained adequately. The shunts with reinforced grafts can keep a higher rate of patency. The morbidity of encephalopathy was lower than those with total shunt. The partial portacaval shunt is effective in preventing recurrent variceal bleeding.

关键词： diameter clinical efficacy bleeding pericardial devascularization Forty-three

HTML PDF 收藏

Differential diagnosis of cervical nerve compression syndrome of the external intervertebral foramen

WANG Jinwu, NI Weifeng, XU Jianguang, ZHU Haibo, GUO Shangchun, ZENG Bingfang, ZHAO Binghui

《医学前沿（英文）》 2007年第1卷第2期页码 177-180 doi: 10.1007/s11684-007-0033-3

摘要： The aim of the present research is to study the mechanism of cervical nerve compression syndrome of the external intervertebral foramen and its differential diagnosis with cervical spondylosis. Diagnostic treatment with muscle relaxant, vasodilator, neurotrophic medicine and celecoxib (COX)-2 inhibitor were performed in 20 patients with cervical nerve compression syndrome of the external intervertebral foramen and 20 patients with cervical spondylosis confirmed by operation. Diagnostic local block therapy was performed additionally in cases showing little effect after diagnostic treatment. All the patients were followed up postoperatively for more than one year. Fifteen cases with cervical nerve compression syndrome of the external intervertebral foramen were healed by the diagnostic treatment. The other five cases had a short-term remission and there was no recurrence after diagnostic local block therapy. Diagnostic treatment led to short-term alleviation of the symptom in 20 cases with cervical spondylosis confirmed by operation, the results of which was far from satisfactory and operation was undertaken finally in all the 20 cases. The etiology of cervical nerve compression syndrome of the external intervertebral foramen lies in the compression of the cervical plexus, brachial plexus and cervical dorsal rami by the tendinous decussating fibers of the scalenus anticus, medius, minimus and the posterior muscles of the neck. Diagnostic treatment was propitious to differentiate cervical nerve compression syndrome of the external intervertebral foramen from cervical spondylosis.

关键词： satisfactory COX minimus operation compression syndrome

HTML PDF 收藏

大鼠周围神经诱发脑皮层电位时空图——一种研究脑对周围神经反应模式的新方法 Article

殷晓峰, 邓玖旭, 陈博, 金博, 谷馨怡, 齐志丹, 冷坤鹏, 姜保国

《工程（英文）》 2022年第14卷第7期页码 147-155 doi: 10.1016/j.eng.2021.04.018

摘要：

将大脑作为一个整体，观察周围神经受到刺激后大脑反应的动态过程，是深入了解脑功能的基础，也是一个科学难题。本研究发展了一种新型大鼠脑皮层诱发电位微创正交记录方法，结果显示，在该方法下，刺激大鼠正中神经、尺神经和桡神经及其分支，首次获得了可重复、具有不同波形特点、可辨别的脑皮层诱发电位图谱，并将其时空变化规律以可视化的方式呈现出来。此外本研究也记录了正中神经离断4个月后，大鼠脑皮层诱发电位的变化。结果表明，大脑皮层对周围神经刺激的反应具有精确和可重复的时空顺序。本实验方法和波形图谱可作为测试平台用于探索周围神经系统和脑中枢神经系统之间的整体功能交互与动态重塑的时相机制。

关键词：周围神经大脑诱发皮层电位时空图谱

HTML PDF 收藏

Contemporary coronary artery bypass grafting

null

《医学前沿（英文）》 2014年第8卷第4期页码 395-398 doi: 10.1007/s11684-014-0374-7

摘要：

Current evidence clearly demonstrates that coronary artery bypass grafting (CABG) remains the “gold standard” treatment for most patients with multivessel and left main stem disease. This article summarizes the relevant evidence basis demonstrating that CABG, in comparison to stenting, reduces mortality and subsequent myocardial infarction and the need for repeat revascularization. The article also describes the evidence basis to support the use of more arterial grafts during CABG and the current role of off-pump CABG.

关键词： coronary artery bypass grafting (CABG) coronary artery disease left main arterial grafts internal mammary artery off-pump CABG

HTML PDF 收藏

非编码RNA及其在组织工程中的潜在应用

李石营, 钱天梅, 王星辉, 刘杰, 顾晓松

《工程（英文）》 2017年第3卷第1期页码 3-15 doi: 10.1016/J.ENG.2017.01.005

摘要：

组织工程是医学科学中一个相对较新但发展迅速的领域。非编码RNA(ncRNA) 是不编码蛋白质的功能性RNA 分子，它们可以调节细胞的行为、改变组织的生物学环境。虽然以对ncRNA 作为治疗靶点尚未进入临床实践，但ncRNA 在组织工程中的应用已经吸引了越来越多的关注，而且对ncRNA 的调节作用和释放方法的深入探讨可以促进其在组织工程中的应用。本文简要介绍了ncRNA 在神经、皮肤、肝脏、血管和肌肉的调控作用和可能的释放方法及其潜在的治疗应用价值。

关键词：组织工程非编码RNA(ncRNA) microRNA(miRNA) 神经皮肤肝脏血管系统肌肉

HTML PDF 收藏

“机械灌注+”应用于扩大标准供肝移植——肝尽其用 Review

王周城, Jack Martin, 余炯杰, 汪恺, Kourosh Saeb-Parsy, 徐骁

《工程（英文）》 2024年第32卷第1期页码 30-41 doi: 10.1016/j.eng.2023.11.003

摘要：

移植是终末期肝病最有效的治疗方法，但由于供体器官的短缺而受到限制。扩大标准供体（ECD）供肝在临床实践中越来越多地用于缓解这一挑战。然而，这些移植物耐受缺血的能力下降，危及冷保存期间器官的活力。机器灌注（MP）旨在改善器官保存并减少移植后并发症。然而，越来越明显的是，单独使用MP无法达到ECD供肝的最佳保存。因此，人们逐渐开始重视改良的 MP 策略，包括使用不同的灌注剂、改良的灌注方式并结合不同的治疗干预策略。本文中，我们提出了“机械灌注+”的新理念，代表这些旨在提升器官功能并可能实现ECD供肝体外再生的机械灌注新策略。为此，我们总结了现有和改良的MP策略，并阐述其在临床场景中修复不同ECD供肝的优势。

关键词：肝移植扩大标准供体机械灌注+ 器官短缺